https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10824 Wed 11 Apr 2018 16:58:46 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13217 Wed 11 Apr 2018 15:39:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36559 Thu 28 Oct 2021 13:03:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1219 Sat 24 Mar 2018 08:28:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21832 Sat 24 Mar 2018 07:58:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26413 1-40 (5 μmol/L) protein is considered to be a model of AD. Hence the aim of this study was to examine the influence of Schizandrol A, a plant extract, on DNA methylation in SH-SY5Y cells exposed to Aβ_1-40. Aβ_1-40 were incubated with varying concentrations of Sehizandrol A to a final concentration of 1 (low), 3 (intermediate) or 9 μg/ml (high). Exposure of SH-SY5Y with Aβ1-40 reduced viability, and altered cellular morphology and mRNA expression of DNA methyltransferase (DNMT3A) and DNMT3B. Treatment with 1 or 3 μg/ml Sehizandrol A resulted in normal cell morphology as well as elevated cell number, enhanced viability, and increased mRNA expression of DNMT3A and DNMT3B compared to saline. However, an increase in Sehizandrol A to 9 μg/ml produced a fall in cell viability, as well as a decrease in mRNA DNMT3A and DNMT3B expression to control levels. Data demonstrated that Schizandrol A at 1 or 3 μg/ml improved cell morphological appearance and viability of Aβ_1-40 injured SH-SY5Y cells by an enhanced DNA methylation pathway.]]> Sat 24 Mar 2018 07:27:56 AEDT ]]>